THE IMPORTANCE OF CHROMOGRANIN A DOSAGE IN NEUROENDOCRINE TUMOURS
نویسندگان
چکیده
منابع مشابه
Clinical significance of blood chromogranin A measurement in neuroendocrine tumours.
BACKGROUND Tumour marker measurement gives clinicians useful information for the follow-up and management of patients with neuroendocrine tumours (NETs). The currently used tumour markers for NETs are neuron-specific enolase (NSE) and chromogranin A (CgA). The clinical accuracy of these biomarkers depends on histotype and disease extent. CgA is thought to be the optimal marker for most NETs, as...
متن کاملChromogranin A in Physiology and Oncology ( chromogranin / neuroendocrine tumours / cleavage fragments / extracellular functions / intracellular functions / tumour marker )
Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH 2 -terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endo...
متن کامل[Chromogranin A and neuroendocrine tumors].
Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly differentiated tumors, it is the best tumor marker ...
متن کاملClinical signi¢cance of blood chromogranin A measurement in neuroendocrine tumours
Background: Tumour marker measurement gives clinicians useful information for the follow-up and management of patients with neuroendocrine tumours (NETs). The currently used tumour markers for NETs are neuron-speci¢c enolase (NSE) and chromogranin A (CgA). The clinical accuracy of these biomarkers depends on histotype and disease extent. CgA is thought to be the optimal marker for most NETs, as...
متن کاملChromogranin A and Neuroendocrine Tumors
A neuroendocrine tumor is suspected when classical clinical symptoms occur but the large majority of NETs does not show any specific symptomatology (Oberg et al., 1999). Accordingly, the biochemical diagnosis is of great value, with the validation of radioimmunoenzymatic assays for various circulating peptide hormones in the last decade, clinical awareness and ability to diagnose NET is increas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Farmacia
سال: 2023
ISSN: ['2065-0019', '0014-8237']
DOI: https://doi.org/10.31925/farmacia.2023.4.14